In Progress!

Lung cancer-kidney cross talk induces kidney injury, interstitial fibrosis and enhances cisplatin-induced nephrotoxicity

Orwick A, Sears SM, Sharp CN, Doll MA, Shah PP, Beverly LJ, Siskind LJ.

Am J Physiol Renal Physiol. 2023 March 1;324(3):F287-300. PMID: 36727944 PMC9988526

Pharmacological inhibitors of autophagy have opposite effects in acute and chronic cisplatin-induced kidney injury

Sears SM, Feng JL, Orwick A, Vega AA, Krueger AM, Shah PP, Doll MA, Beverly LJ, Siskind LJ.

Am J Physiol Renal Physiol. 2022 Sep; 323(3):F288-F298.  PMID: 35796459 PMC9394729

F4/80hi resident macrophages contribute to cisplatin-induced renal fibrosis.

Sears SM, Vega AA, Kurlawala Z, Oropilla GB, Krueger A, Shah PP, Doll MA, Miller R, Beverly LJ and Siskind LJ.

Kidney360 May 2022, 3(5)818-833. 

Loss of the Na+/H+ Exchange Regulatory Factor 1 Increases Susceptibility to Cisplatin-Induced Acute Kidney Injury.

Bushau-Sprinkle A, Barati M, Conklin C, Dupre T, Gagnon KB, Khundmiri SJ, Clark B, Siskind L, Doll MA, Rane M, Brier M, Coventry S, Lederer ED.

Am J Pathol. 2019 Jun;189(6):1190-1200. doi: 10.1016/j.ajpath.2019.02.010. Epub 2019 Mar 27.

PMID: 30926337

Moderate aging does not exacerbate cisplatin-induced kidney injury or fibrosis despite altered inflammatory cytokine expression and immune cell infiltration.

Sharp CN, Doll M, Dupre TV, Beverly LJ, Siskind LJ.

Am J Physiol Renal Physiol. 2019 Jan 1;316(1):F162-F172. doi: 10.1152/ajprenal.00463.2018. Epub 2018 Nov 28.

PMID: 30484347

The role of sphingolipids in acute kidney injury.

Dupre TV, Siskind LJ.

Adv Biol Regul. 2018 Dec;70:31-39. doi: 10.1016/j.jbior.2018.11.003. Epub 2018 Nov 13. Review.

PMID: 30455062

Subclinical kidney injury induced by repeated cisplatin administration results in progressive chronic kidney disease.

Sharp CN, Doll MA, Megyesi J, Oropilla GB, Beverly LJ, Siskind LJ.

Am J Physiol Renal Physiol. 2018 Jul 1;315(1):F161-F172. doi: 10.1152/ajprenal.00636.2017. Epub 2018 Jan 31.

PMID: 29384415 Free PMC Article

Developing better mouse models to study cisplatin-induced kidney injury.

Sharp CN, Siskind LJ.

Am J Physiol Renal Physiol. 2017 Oct 1;313(4):F835-F841. doi: 10.1152/ajprenal.00285.2017. Epub 2017 Jul 19. Review.

PMID: 28724610 Free PMC Article

Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury.

Dupre TV, Doll MA, Shah PP, Sharp CN, Siow D, Megyesi J, Shayman J, Bielawska A, Bielawski J, Beverly LJ, Hernandez-Corbacho M, Clarke CJ, Snider AJ, Schnellmann RG, Obeid LM, Hannun YA, Siskind LJ.

J Lipid Res. 2017 Jul;58(7):1439-1452. doi: 10.1194/jlr.M076745. Epub 2017 May 10.

PMID: 28490444 Free PMC Article

Bridging translation for acute kidney injury with better preclinical modeling of human disease.

Skrypnyk NI, Siskind LJ, Faubel S, de Caestecker MP.

Am J Physiol Renal Physiol. 2016 May 15;310(10):F972-84. doi: 10.1152/ajprenal.00552.2015. Epub 2016 Mar 9. Review.

PMID: 26962107 Free PMC Article

Repeated administration of low-dose cisplatin in mice induces fibrosis.

Sharp CN, Doll MA, Dupre TV, Shah PP, Subathra M, Siow D, Arteel GE, Megyesi J, Beverly LJ, Siskind LJ.

Am J Physiol Renal Physiol. 2016 Mar 15;310(6):F560-8. doi: 10.1152/ajprenal.00512.2015. Epub 2016 Jan 6.

PMID: 26739893 Free PMC Article

 Suramin protects from cisplatin-induced acute kidney injury.

Dupre TV, Doll MA, Shah PP, Sharp CN, Kiefer A, Scherzer MT, Saurabh K, Saforo D, Siow D, Casson L, Arteel GE, Jenson AB, Megyesi J, Schnellmann RG, Beverly LJ, Siskind LJ.

Am J Physiol Renal Physiol. 2016 Feb 1;310(3):F248-58. doi: 10.1152/ajprenal.00433.2015. Epub 2015 Dec 9.

PMID: 26661653 Free PMC Article

Kidney glycosphingolipids are elevated early in diabetic nephropathy and mediate hypertrophy of mesangial cells.

Subathra M, Korrapati M, Howell LA, Arthur JM, Shayman JA, Schnellmann RG, Siskind LJ.

Am J Physiol Renal Physiol. 2015 Aug 1;309(3):F204-15. doi: 10.1152/ajprenal.00150.2015. Epub 2015 Jun 3.

PMID: 26041445 Free PMC Article